U.S. is #1 in biomed research, but this country’s catching up

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Scientists in the United States still publish more biomedical research discoveries than those in any other country, but scientists from China are catching up, increasing spending on research and development, a new study shows.

Chinese biomedical research teams now rank fourth in the world for total number of new discoveries published in six top-tier journals, and the country spent three-quarters what the US spent on research and development during 2015. The US leads the world in research and development expenditures.

Slowing spending

Meanwhile, the analysis shows, scientists from the US and other countries increasingly make discoveries and advancements as part of teams that involve researchers from around the world.

The last 15 years have ushered in an era of “team science” as research funding in the US, Great Britain, and other European countries, as well as Canada and Australia, stagnated. The number of authors has also grown over time. For example, in 2000 only two percent of the research papers the new study looked include 21 or more authors—a number that increased to 12.5 percent in 2015.

“If we continue on the path we’re on, it will be harder to maintain our lead…”

The new findings, published in JCI Insight by a team of researchers, come at a critical time for the debate over the future of US federal research funding. The study is based on a careful analysis of original research papers published in six top-tier and four mid-tier journals from 2000 to 2015, in addition to data on R&D investment from those same years.

The study builds on other work that has also warned of America’s slipping status in the world of science and medical research, and the resulting impact on the next generation of aspiring scientists.

“It’s time for US policy-makers to reflect and decide whether the year-to-year uncertainty in National Institutes of Health budget and the proposed cuts are in our societal and national best interest,” says Bishr Omary, senior author of the new data-supported opinion piece and chief scientific officer of Michigan Medicine, the University of Michigan’s academic medical center.

“If we continue on the path we’re on, it will be harder to maintain our lead and, even more importantly, we could be disenchanting the next generation of bright and passionate biomedical scientists who see a limited future in pursuing a scientist or physician-investigator career,” he says.

The analysis charts South Korea’s entry into the top 10 countries for publications, as well as China’s leap from outside the top 10 in 2000 to fourth place in 2015. They also track the major increases in support for research in South Korea and Singapore since the start of the 21st Century.

Working globally

First author of the study informationist Marisa Conte and Omary co-led a team that looked carefully at the currency of modern science: peer-reviewed basic science and clinical research papers describing new findings, published in journals with long histories of accepting among the world’s most significant discoveries.

They reviewed every issue of six top-tier international journals (JAMA, LancetNew England Journal of Medicine, Cell, Nature, and Science), and four mid-ranking journals (British Medical Journal, JAMA Internal Medicine, Journal of Cell Science, FASEB Journal), chosen to represent the clinical and basic science aspects of research.

The analysis included only papers that reported new results from basic research experiments, translational studies, clinical trials, metanalyses, and studies of disease outcomes. Author affiliations for corresponding authors and all other authors were recorded by country.

The rise in global cooperation is striking. In 2000, 25 percent of papers in the six top-tier journals were by teams that included researchers from at least two countries. In 2015, that figure was closer to 50 percent. The increasing need for multidisciplinary approaches to make major advances, coupled with the advances of internet-based collaboration tools, likely have something to do with this, Omary says.

The next generation

The authors note that part of their group’s interest in doing the study sprang from their hypothesis that a flat NIH budget is likely to have negative consequences but they wanted to gather data to test their hypothesis.

They also observed what appears to be an increasing number of Chinese-born scientists who had trained in the US going back to China after their training, where once most of them would have sought to stay in the US. In addition, Singapore has been able to recruit several top notch US and other international scientists due to their marked increase in R&D investments.

The same trends appear to be happening in Great Britain, Australia, Canada, France, Germany, and other countries the authors studied—where research investing has stayed consistent when measured as a percentage of the US total over the last 15 years.

The authors note that their study is based on data up to 2015, and that in the current 2017 federal fiscal year, funding for NIH has increased thanks to bipartisan Congressional appropriations.

The NIH contributes to most of the federal support for medical and basic biomedical research in the US. But discussion of cuts to research funding that hinders many federal agencies is in the air during the current debates for the 2018 budget. Meanwhile, the Chinese R&D spending is projected to surpass the US total by 2022.

“Our analysis, albeit limited to a small number of representative journals, supports the importance of financial investment in research,” Omary says. “I would still strongly encourage any child interested in science to pursue their dream and passion, but I hope that our current and future investment in NIH and other federal research support agencies will rise above any branch of government to help our next generation reach their potential and dreams.”

This text is published here under a Creative Commons License.
Author: Kara Gavin-University of Michigan
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